April 20, 2011

An updated tree of Y-chromosome Haplogroup O (Yan et al. 2011)

European Journal of Human Genetics advance online publication 20 April 2011; doi: 10.1038/ejhg.2011.64

An updated tree of Y-chromosome Haplogroup O and revised phylogenetic positions of mutations P164 and PK4

Shi Yan et al.

Y-chromosome Haplogroup O is the dominant lineage of East Asians, comprising more than a quarter of all males on the world; however, its internal phylogeny remains insufficiently investigated. In this study, we determined the phylogenetic position of recently defined markers (L127, KL1, KL2, P164, and PK4) in the background of Haplogroup O. In the revised tree, subgroup O3a-M324 is divided into two main subclades, O3a1-L127 and O3a2-P201, covering about 20 and 35% of Han Chinese people, respectively. The marker P164 is corrected from a downstream site of M7 to upstream of M134 and parallel to M7 and M159. The marker PK4 is also relocated from downstream of M88 to upstream of M95, separating the former O2* into two parts. This revision evidently improved the resolving power of Y-chromosome phylogeny in East Asia.

Link

5 comments:

Jensen said...

The full paper:
http://ranhaer.com/viewthread.php?tid=15255&page=1#pid223368

terryt said...

It will be interesting to view the adjusted tree. There may be enough information in the abstract to get some idea.

sykes.1 said...

I apologize for being off-topic. However, the links to the papers under "Articles" have been hijacked by 50Webs and WE.BS and are being used to sell domain hosting packages.

Andrew Oh-Willeke said...

@ Jenson

Thanks.

Eyeballing the table (although you'd really want to do a Chi square statistic with the appropriate degrees of freedom), it isn't obvious that there are any statistically significant deviations from a homogeneous mix of haplogroups - which would suggest expansion of the Han Chinese population only after the haplogroups had differentiated in a compact geographic are of origin for the expansion.

Given the mostly historically known time frame for Han Chinese expansion and a bit of an order of magnitude sense of how fast Y-DNA mutates, that seems like a plausible possiblity.

terryt said...

"which would suggest expansion of the Han Chinese population only after the haplogroups had differentiated in a compact geographic are of origin for the expansion".

Not just the Han would be my guess. The O haplogroup expansion goes back a little before the Han. The Han are just the last of the series. I'm sure that the 'compact geographic are of origin' for Y-hap O is the Chinese Neolithic of the Yangtze/Yellow River basins.