October 08, 2015

West Eurasian admixture throughout Africa (?)

In 2012, I wrote:
It is no longer tenable to view West Eurasian back-migrations as limited events that affected only North and East Africa: their effects are clearly evident throughout Africa, having affected different populations to a different extent.
A new paper in Science seems to confirm West Eurasian admixture related to Early Neolithic farmers throughout Africa, including the Yoruba, and Mbuti. I haven't read the paper yet, but it would be a striking discovery if confirmed.

Science DOI: 10.1126/science.aad2879

Ancient Ethiopian genome reveals extensive Eurasian admixture throughout the African continent

M. Gallego Llorente et al

Characterizing genetic diversity in Africa is a crucial step for most analyses reconstructing the evolutionary history of anatomically modern humans. However, historic migrations from Eurasia into Africa have affected many contemporary populations, confounding inferences. Here, we present a 12.5x coverage ancient genome of an Ethiopian male (‘Mota’) who lived approximately 4,500 years ago. We use this genome to demonstrate that the Eurasian backflow into Africa came from a population closely related to Early Neolithic farmers, who had colonized Europe 4,000 years earlier. The extent of this backflow was much greater than previously reported, reaching all the way to Central, West and Southern Africa, affecting even populations such as Yoruba and Mbuti, previously thought to be relatively unadmixed, who harbor 6-7% Eurasian ancestry.


September 19, 2015

Recent admixture in contemporary West Eurasians

After applying Globetrotter to the world and to the British, a new study in Current Biology applies to the intermediately-sized region of West Eurasia. This is an open-access article, so go ahead and read it.

Current Biology DOI: http://dx.doi.org/10.1016/j.cub.2015.08.007

The Role of Recent Admixture in Forming the Contemporary West Eurasian Genomic Landscape
George B.J. Busby et al.

Over the past few years, studies of DNA isolated from human fossils and archaeological remains have generated considerable novel insight into the history of our species. Several landmark papers have described the genomes of ancient humans across West Eurasia, demonstrating the presence of large-scale, dynamic population movements over the last 10,000 years, such that ancestry across present-day populations is likely to be a mixture of several ancient groups [ 1–7 ]. While these efforts are bringing the details of West Eurasian prehistory into increasing focus, studies aimed at understanding the processes behind the generation of the current West Eurasian genetic landscape have been limited by the number of populations sampled or have been either too regional or global in their outlook [ 8–11 ]. Here, using recently described haplotype-based techniques [ 11 ], we present the results of a systematic survey of recent admixture history across Western Eurasia and show that admixture is a universal property across almost all groups. Admixture in all regions except North Western Europe involved the influx of genetic material from outside of West Eurasia, which we date to specific time periods. Within Northern, Western, and Central Europe, admixture tended to occur between local groups during the period 300 to 1200 CE. Comparisons of the genetic profiles of West Eurasians before and after admixture show that population movements within the last 1,500 years are likely to have maintained differentiation among groups. Our analysis provides a timeline of the gene flow events that have generated the contemporary genetic landscape of West Eurasia.


September 18, 2015

Political (non) diversity in social psychology

Behavioral and Brain Sciences / Volume 38 / January 2015, e130 (13 pages)

Political diversity will improve social psychological science

José L. Duartea1, Jarret T. Crawforda2, Charlotta Sterna3, Jonathan Haidta4, Lee Jussima5 and Philip E. Tetlocka6

Psychologists have demonstrated the value of diversity – particularly diversity of viewpoints – for enhancing creativity, discovery, and problem solving. But one key type of viewpoint diversity is lacking in academic psychology in general and social psychology in particular: political diversity. This article reviews the available evidence and finds support for four claims: (1) Academic psychology once had considerable political diversity, but has lost nearly all of it in the last 50 years. (2) This lack of political diversity can undermine the validity of social psychological science via mechanisms such as the embedding of liberal values into research questions and methods, steering researchers away from important but politically unpalatable research topics, and producing conclusions that mischaracterize liberals and conservatives alike. (3) Increased political diversity would improve social psychological science by reducing the impact of bias mechanisms such as confirmation bias, and by empowering dissenting minorities to improve the quality of the majority's thinking. (4) The underrepresentation of non-liberals in social psychology is most likely due to a combination of self-selection, hostile climate, and discrimination. We close with recommendations for increasing political diversity in social psychology.


August 13, 2015

Rethinking the dispersal of Homo sapiens out of Africa

An excellent review which -among its other graces- demolishes the view that mtDNA haplogroup L3 provides a terminus post quem of 70 thousand years for the Out-of-Africa expansion, a question I've discussed in this blog before.

I think the evidence is overwhelming at this point that there were modern humans outside Africa before 100,000 years ago. The argument that they were a  failed expansion is shoddy and is based, as far as I can tell on things like the age of L3, the assumption that Y-chromosome haplogroup E is native to Africa and not derived from back-to-Africa migrants, the assumption that Out-of-Africa coincided with the Upper Paleolithic cultural efflorescence (disproven by the earlier dating of Neandertal admixture), or the failed hypothesis of a coastal route Out of Africa 60 thousand years ago that seems to be repeated in inverse proportion to the evidence for it. The halving of the human autosomal mutation rate relative to what was inferred before has certainly not helped either.

Evolutionary Anthropology: Issues, News, and Reviews Volume 24, Issue 4, pages 149–164, July/August 2015

Rethinking the dispersal of Homo sapiens out of Africa

Huw S. Groucutt, Michael D. Petraglia, Geoff Bailey, Eleanor M. L. Scerri, Ash Parton, Laine Clark-Balzan, Richard P. Jennings, Laura Lewis, James Blinkhorn, Nick A. Drake, Paul S. Breeze, Robyn H. Inglis, Maud H. Devès, Matthew Meredith-Williams, Nicole Boivin, Mark G. Thomas andAylwyn Scally

Current fossil, genetic, and archeological data indicate that Homo sapiens originated in Africa in the late Middle Pleistocene. By the end of the Late Pleistocene, our species was distributed across every continent except Antarctica, setting the foundations for the subsequent demographic and cultural changes of the Holocene. The intervening processes remain intensely debated and a key theme in hominin evolutionary studies. We review archeological, fossil, environmental, and genetic data to evaluate the current state of knowledge on the dispersal of Homo sapiens out of Africa. The emerging picture of the dispersal process suggests dynamic behavioral variability, complex interactions between populations, and an intricate genetic and cultural legacy. This evolutionary and historical complexity challenges simple narratives and suggests that hybrid models and the testing of explicit hypotheses are required to understand the expansion of Homo sapiens into Eurasia.

Link and here

August 12, 2015

Mesolithic monolith from Sicilian Channel

Journal of Archaeological Science: Reports Volume 3, September 2015, Pages 398–407

A submerged monolith in the Sicilian Channel (central Mediterranean Sea): Evidence for Mesolithic human activity

Emanuele Lodolo, Zvi Ben-Avraham

The ancient geography of the Mediterranean Basin was profoundly changed by the increase in sea level following the Last Glacial Maximum. This global event has led to the retreat of the coastlines, especially in lowland areas and shallow shelves, such as the Sicilian Channel. The NW sector of this shelf, known as Adventure Plateau, is studded by isolated shoals mostly composed of Late Miocene carbonate rocks and by some volcanic edifices. These shoals, until at least the Early Holocene, formed an archipelago of several islands separated by stretches of extremely shallow sea. One of these submerged features – the Pantelleria Vecchia Bank – located 60 km south of Sicily, has been extensively surveyed using geophysical and geological methods. It is composed of two main shoals, connected seaward by a rectilinear ridge which encloses an embayment. Here we present morphological evidence, underwater observations, and results of petrographic analysis of a man-made, 12 m long monolith resting on the sea-floor of the embayment at a water depth of 40 m. It is broken into two parts, and has three regular holes: one at its end which passes through from part to part, the others in two of its sides. The monolith is composed of calcirudites of Late Pleistocene age, as determined from radiocarbon measurements conducted on several shell fragments extracted from the rock samples. The same age and composition characterize the metre-size blocks forming the rectilinear ridge. The rest of the rocks composing the shoals are mostly Tortonian limestones–sandstones, as revealed by their fossil content. Extrapolating ages from the local sea level curve, we infer that seawater inundated the inner lands at 9350 ± 200 year B.P., the upper limit which can be reasonably taken for the site abandonment. This discovery provides evidence for a significant Mesolithic human activity in the Sicilian Channel region.


August 07, 2015

Prehistoric farmers from northern Greece had lactose intolerance, brown eyes, dark skin

According to this:
Πολύ σημαντικό πρόσφατο εύρημα αποτελεί η ανάκτηση ολόκληρων γονιδιωμάτων από τρεις προϊστορικούς αγρότες, που έζησαν στη Βόρεια Ελλάδα 7.500 με 5.500 χρόνια πριν από σήμερα. Τα δεδομένα αυτά αναλύονται και αναμένεται να ρίξουν φως στις προγονικές σχέσεις των πρώτων Ευρωπαίων και να δώσουν πλήθος πληροφοριών, που συνδέονται με λειτουργικά και μορφολογικά χαρακτηριστικά. Ήδη, είναι γνωστό, ότι κάποιοι νεολιθικοί πρόγονοί μας δε μπορούσαν να πέψουν το γάλα, ήταν δηλαδή δυσανεκτικοί στη λακτόζη και είχαν καστανά μάτια και σκουρόχρωμη επιδερμίδα.
Related video:

July 26, 2015

Paleoamericans galore

Two new papers in Nature and Science add to the debate on Native American origins. The first study (in Nature) detects that some Amazonians have a few percent ancestry from a group related to Australasians, which suggests that early native Americans were not homogeneous but came in two flavors: the main one found all over the Americans and the Australasian-related one. The second study (in Science) looks at ancient "Paleoamerican"-postulated populations and finds that they don't have any particular relationship to Australasians. Thus, whatever population brought the "Paleoamerican" admixture into the Amazon, it remains to be found.

Nature (2015) doi:10.1038/nature14895

Genetic evidence for two founding populations of the Americas 

Pontus Skoglund et al.

Genetic studies have consistently indicated a single common origin of Native American groups from Central and South America1, 2, 3, 4. However, some morphological studies have suggested a more complex picture, whereby the northeast Asian affinities of present-day Native Americans contrast with a distinctive morphology seen in some of the earliest American skeletons, which share traits with present-day Australasians (indigenous groups in Australia, Melanesia, and island Southeast Asia)5, 6, 7, 8. Here we analyse genome-wide data to show that some Amazonian Native Americans descend partly from a Native American founding population that carried ancestry more closely related to indigenous Australians, New Guineans and Andaman Islanders than to any present-day Eurasians or Native Americans. This signature is not present to the same extent, or at all, in present-day Northern and Central Americans or in a ~12,600-year-old Clovis-associated genome, suggesting a more diverse set of founding populations of the Americas than previously accepted.


Science DOI: 10.1126/science.aab3884

Genomic evidence for the Pleistocene and recent population history of Native Americans

Maanasa Raghavan1,*, Matthias Steinrücken2,3,4,*, Kelley Harris5,*, Stephan Schiffels6,*, Simon Rasmussen7,*, Michael DeGiorgio8,*, Anders Albrechtsen9,*, Cristina Valdiosera1,10,*, María C. Ávila-Arcos1,11,*, Anna-Sapfo Malaspinas1* et al.

How and when the Americas were populated remains contentious. Using ancient and modern genome-wide data, we find that the ancestors of all present-day Native Americans, including Athabascans and Amerindians, entered the Americas as a single migration wave from Siberia no earlier than 23 thousand years ago (KYA), and after no more than 8,000-year isolation period in Beringia. Following their arrival to the Americas, ancestral Native Americans diversified into two basal genetic branches around 13 KYA, one that is now dispersed across North and South America and the other is restricted to North America. Subsequent gene flow resulted in some Native Americans sharing ancestry with present-day East Asians (including Siberians) and, more distantly, Australo-Melanesians. Putative ‘Paleoamerican’ relict populations, including the historical Mexican Pericúes and South American Fuego-Patagonians, are not directly related to modern Australo-Melanesians as suggested by the Paleoamerican Model.


July 21, 2015

British origins (with ancient data)


bioRxiv http://dx.doi.org/10.1101/022723

Iron Age and Anglo-Saxon genomes from East England reveal British migration history

Stephan Schiffels, Wolfgang Haak, Pirita Paajanen, Bastien Llamas, Elizabeth Popescu, Louise Lou, Rachel Clarke, Alice Lyons, Richard Mortimer, Duncan Sayer, Chris Tyler-Smith, Alan Cooper, Richard Durbin

British population history has been shaped by a series of immigrations and internal movements, including the early Anglo-Saxon migrations following the breakdown of the Roman administration after 410CE. It remains an open question how these events affected the genetic composition of the current British population. Here, we present whole-genome sequences generated from ten ancient individuals found in archaeological excavations close to Cambridge in the East of England, ranging from 2,300 until 1,200 years before present (Iron Age to Anglo-Saxon period). We use present-day genetic data to characterize the relationship of these ancient individuals to contemporary British and other European populations. By analyzing the distribution of shared rare variants across ancient and modern individuals, we find that today’s British are more similar to the Iron Age individuals than to most of the Anglo-Saxon individuals, and estimate that the contemporary East English population derives 30% of its ancestry from Anglo-Saxon migrations, with a lower fraction in Wales and Scotland. We gain further insight with a new method, rarecoal, which fits a demographic model to the distribution of shared rare variants across a large number of samples, enabling fine scale analysis of subtle genetic differences and yielding explicit estimates of population sizes and split times. Using rarecoal we find that the ancestors of the Anglo-Saxon samples are closest to modern Danish and Dutch populations, while the Iron Age samples share ancestors with multiple Northern European populations including Britain.


July 12, 2015

Phylogeographic refinement of haplogroup E

Genome Biol Evol (2015) 7 (7): 1940-1950.

Phylogeographic Refinement and Large Scale Genotyping of Human Y Chromosome Haplogroup E Provide New Insights into the Dispersal of Early Pastoralists in the African Continent

Beniamino Trombetta et al.

Haplogroup E, defined by mutation M40, is the most common human Y chromosome clade within Africa. To increase the level of resolution of haplogroup E, we disclosed the phylogenetic relationships among 729 mutations found in 33 haplogroup DE Y-chromosomes sequenced at high coverage in previous studies. Additionally, we dissected the E-M35 subclade by genotyping 62 informative markers in 5,222 samples from 118 worldwide populations. The phylogeny of haplogroup E showed novel features compared with the previous topology, including a new basal dichotomy. Within haplogroup E-M35, we resolved all the previously known polytomies and assigned all the E-M35* chromosomes to five new different clades, all belonging to a newly identified subhaplogroup (E-V1515), which accounts for almost half of the E-M35 chromosomes from the Horn of Africa. Moreover, using a Bayesian phylogeographic analysis and a single nucleotide polymorphism-based approach we localized and dated the origin of this new lineage in the northern part of the Horn, about 12 ka. Time frames, phylogenetic structuring, and sociogeographic distribution of E-V1515 and its subclades are consistent with a multistep demic spread of pastoralism within north-eastern Africa and its subsequent diffusion to subequatorial areas. In addition, our results increase the discriminative power of the E-M35 haplogroup for use in forensic genetics through the identification of new ancestry-informative markers.


Y-chromosomes of Sicilian and Calabrian Arbereshe

European Journal of Human Genetics advance online publication 1 July 2015; doi: 10.1038/ejhg.2015.138

Shared language, diverging genetic histories: high-resolution analysis of Y-chromosome variability in Calabrian and Sicilian Arbereshe

Stefania Sarno et al.

The relationship between genetic and linguistic diversification in human populations has been often explored to interpret some specific issues in human history. The Albanian-speaking minorities of Sicily and Southern Italy (Arbereshe) constitute an important portion of the ethnolinguistic variability of Italy. Their linguistic isolation from neighboring Italian populations and their documented migration history, make such minorities particularly effective for investigating the interplay between cultural, geographic and historical factors. Nevertheless, the extent of Arbereshe genetic relationships with the Balkan homeland and the Italian recipient populations has been only partially investigated. In the present study we address the genetic history of Arbereshe people by combining highly resolved analyses of Y-chromosome lineages and extensive computer simulations. A large set of slow- and fast-evolving molecular markers was typed in different Arbereshe communities from Sicily and Southern Italy (Calabria), as well as in both the putative Balkan source and Italian sink populations. Our results revealed that the considered Arbereshe groups, despite speaking closely related languages and sharing common cultural features, actually experienced diverging genetic histories. The estimated proportions of genetic admixture confirm the tight relationship of Calabrian Arbereshe with modern Albanian populations, in accordance with linguistic hypotheses. On the other hand, population stratification and/or an increased permeability of linguistic and geographic barriers may be hypothesized for Sicilian groups, to account for their partial similarity with Greek populations and their higher levels of local admixture. These processes ultimately resulted in the differential acquisition or preservation of specific paternal lineages by the present-day Arbereshe communities.


mtDNA from Xiaohe cemetery

BMC Genetics 2015, 16:78 doi:10.1186/s12863-015-0237-5

Analysis of ancient human mitochondrial DNA from the Xiaohe cemetery: insights into prehistoric population movements in the Tarim Basin, China

Chunxiang Li et al.



The Tarim Basin in western China, known for its amazingly well-preserved mummies, has been for thousands of years an important crossroad between the eastern and western parts of Eurasia. Despite its key position in communications and migration, and highly diverse peoples, languages and cultures, its prehistory is poorly understood. To shed light on the origin of the populations of the Tarim Basin, we analysed mitochondrial DNA polymorphisms in human skeletal remains excavated from the Xiaohe cemetery, used by the local community between 4000 and 3500 years before present, and possibly representing some of the earliest settlers.


Xiaohe people carried a wide variety of maternal lineages, including West Eurasian lineages H, K, U5, U7, U2e, T, R*, East Eurasian lineages B, C4, C5, D, G2a and Indian lineage M5.


Our results indicate that the people of the Tarim Basin had a diverse maternal ancestry, with origins in Europe, central/eastern Siberia and southern/western Asia. These findings, together with information on the cultural context of the Xiaohe cemetery, can be used to test contrasting hypotheses of route of settlement into the Tarim Basin.


Complex demographic history of Western Central African Pygmies

bioRxiv doi: http://dx.doi.org/10.1101/022194

Whole genome sequence analyses of Western Central African Pygmy hunter-gatherers reveal a complex demographic history and identify candidate genes under positive natural selection

PingHsun Hsieh et al.

African Pygmies practicing a mobile hunter-gatherer lifestyle are phenotypically and genetically diverged from other anatomically modern humans, and they likely experienced strong selective pressures due to their unique lifestyle in the Central African rainforest. To identify genomic targets of adaptation, we sequenced the genomes of four Biaka Pygmies from the Central African Republic and jointly analyzed these data with the genome sequences of three Baka Pygmies from Cameroon and nine Yoruba famers. To account for the complex demographic history of these populations that includes both isolation and gene flow, we fit models using the joint allele frequency spectrum and validated them using independent approaches. Our two best-fit models both suggest ancient divergence between the ancestors of the farmers and Pygmies, 90,000 or 150,000 years ago. We also find that bi-directional asymmetric gene-flow is statistically better supported than a single pulse of unidirectional gene flow from farmers to Pygmies, as previously suggested. We then applied complementary statistics to scan the genome for evidence of selective sweeps and polygenic selection. We found that conventional statistical outlier approaches were biased toward identifying candidates in regions of high mutation or low recombination rate. To avoid this bias, we assigned P-values for candidates using whole-genome simulations incorporating demography and variation in both recombination and mutation rates. We found that genes and gene sets involved in muscle development, bone synthesis, immunity, reproduction, cell signaling and development, and energy metabolism are likely to be targets of positive natural selection in Western African Pygmies or their recent ancestors.


July 05, 2015

Γιατί πρέπει να ψηφίσουμε ΝΑΙ στις 5 Ιουλίου

Απευθύνω το παρόν σε όσους ειλικρινά πιστεύουν πως βοηθούν την Ελλάδα ψηφίζοντας Όχι στο δημοψήφισμα της 5 Ιουλίου.

Υπάρχουν φυσικά και οι άλλοι, οι οποίοι υστερόβουλα θέλουν να επικρατήσει το Όχι: είτε γιατί έχουν διαφυλάξει τα χρήματα τους σε θυρίδες ή το εξωτερικό και προσδοκούν να κερδίσουν από τη δραχμή, είτε γιατί προσβλέπουν σε μια καταστροφική προεπαναστατική κατάσταση που θα τους βοηθήσει να αδράξουν την εξουσία.

Υπάρχουν όμως και ορισμένοι που ειλικρινά πιστεύουν πως το Όχι θα βοηθήσει την πατρίδα. Σ'αυτούς λοιπόν απευθύνομαι. Είτε πιστεύετε πως με το Όχι θα επιτευχθεί μια καλύτερη συμφωνία για την Ελλάδα, είτε θεωρείτε πως το Όχι είναι ζήτημα εθνικής ανεξαρτησίας και περηφάνιας και νομίζετε πως μετά από τόσο χρόνια κηδεμονίας από την Τρόικα ήρθε ο καιρός να ανακτήσουμε τις τύχες της χώρας μας.

Αν πιστεύετε πως το Όχι θα οδηγήσει σε μια καλύτερη συμφωνία, αναρωτηθείτε πώς θα το εκλάβουν στο εξωτερικό, αφού με τους ξένους πιστωτές θα πρέπει τελικά να συνενοηθούμε.

Οι μεν, που θέλουν την Ελλάδα εκτός Ευρωζώνης, θα εκλάβουν φυσικά το Όχι ως εκδήλωση της βούλησης του Ελληνικού λαού να απορρίψει τα προγράμματα βοήθειας που επιτρέπουν την συνεχιζόμενη παραμονή της χώρας στη νομισματική ένωση.

Οι δε, που επιθυμούν ακόμα την παραμονή της Ελλάδας στην Ευρωζώνη, δεν μπορούν να προσφέρουν κάτι καλύτερο, γιατί από τη μια θα κατηγορηθούν πως ενέδωσαν στον εκβιασμό της Ελλάδας και θα γίνουν ευάλωτοι σε ανάλογους εκβιασμούς από άλλες χώρες με δημοσιονομικό πρόβλημα.

Επιπλέον, η δημοσιονομική επιδείνωση εξαιτίας του κλεισίματος των τραπεζών οδηγεί σε μεγαλύτερη ύφεση την οικονομία και αυξάνει την ανάγκη προσαρμογής. Απορρίπτοντας την συμφωνία, ο Ελληνικός λαός δεν θα πάρει μια καλύτερη συμφωνία -αν πάρει καν μια συμφωνία- αλλά μια χειρότερη, αφού, προφανώς, η υπάρχουσα πρόταση -πέρα από το ότι δεν υπάρχει επισήμως πλέον στο τραπέζι- θα έχει απορριφθεί συνάμα και από τον Ελληνικό λαό.

Αλλά κι ακόμα κι αν οι έξω θελήσουν να επιτύχουν συμφωνία μετά το Όχι, τί σας κάνει να πιστεύετε πως οι έσω θα την επιτύχουν; Επί πέντε μήνες προσπαθούσαν τάχα να κάνουν συμφωνία, οδηγώντας την πραγματική οικονομία σε ολοένα και χειρότερη κατάσταση. Όταν κάποιος που δεν κατόρθωσε να φέρει συμφωνία σε πέντε μήνες υποστηρίζει πως θα την επιτύχει σε μια ώρα (Βαρουφάκης) ή 48 ώρες (Τσίπρας), λογικό είναι να δυσπιστούμε στην έπαρση τους.

Αλλά κι αν νομίζετε πως πράγματι δεν θα υπάρχει καλύτερη συμφωνία και η Ελλάδα θα οδηγηθεί στη Δραχμή, αναλογιστείτε τις συνέπειες σε ανθρώπινη δυστυχία που θα σημάνει μια τέτοια προοπτική σε μια χώρα εξαρτημένη από τις εισαγωγές για βασικά αγαθά όπως τα τρόφιμα, φάρμακα, και καύσιμα. Κι ακόμα -αν υποτεθεί- πως η περίοδος προσαρμογής είναι βραχύβια και η οικονομία αρχίσει πάλι να αναπτύσσεται, νομίζετε πραγματικά πως αυτό θα ωφελήσει την πατρίδα; Άλλωστε ο υπερδανεισμός, η αποσάρθρωση της παραγωγής, το πελατειακό κράτος και όλα όσα οδήγησαν την Ελλάδα στην καταστροφή γεννήθηκαν και άνθισαν και επί δραχμής. Δεν είναι το νόμισμα που οδηγεί μια κοινωνία στην ευμάρεια αλλά η συνετή ή μη χρήση της νομισματικής πολιτικής.

Αν πάλι νομίζετε πως το Όχι είναι ζήτημα αξιοπρέπειας και εθνικής περηφάνιας, σκεφτείτε πως η πραγματική περηφάνια δεν προέρχεται από το να έχεις τη δυνατότητα να κάνεις αυτό που θες εσύ, αλλά από το να κάνεις σε κάθε περίσταση αυτό που είναι χρήσιμο και σωστό, είτε το έχεις σκεφτεί μόνος του (όπως θα έπρεπε) είτε κατ' ανάγκη επειδή αυτό επιβάλλεται από κάποιον άλλο.

Τόσα χρόνια, οι ψηφισμένες Ελληνικές κυβερνήσεις έκαναν αυτό που ήθελαν, χωρίς να ρωτάνε κανένα ξένο πιστωτή, εφόσον μπορούσαν ακόμα να δανείζονται από τις αγορές. Ήταν πραγματικά περήφανες και αξιοπρεπείς ή έσκαβαν, με τη διόγκωση του χρέους, το λάκο στον οποίο στη συνέχεια έπεσε ολόκληρη η χώρα;

Ή ήταν αναξιοπρεπές πως χάρη στους ξένους πιστωτές και τις προσταγές τους άνοιξε η συζήτηση για κάποιες προφανείς αδυναμίες του Ελληνικού Δημοσίου όπως το πελατειακό κράτος με τους υπεράριθμους δημόσιους υπαλλήλους, τα μαϊμού επιδόματα, η συνταξιοδότηση ανθρώπων στο άνθος της παραγωγικής τους ηλικίας, τα ρετιρέ του Δημοσίου, και μια σειρά από άλλες ατέλειες της οργάνωσης της Ελληνικής πολιτείας που -εξαιτίας της χρηματοδοτικής ασφυξίας- αναγκαζόμαστε να αντιμετωπίσουμε.

Όλα αυτά φυσικά δεν ήταν άγνωστα στην Ελληνική κοινωνία στην προ-Μνημονιακή εποχή. Λίγο πολύ όλοι τα γνωρίζαμε αλλά οι περισσότεροι τα θεωρούσαν ήσσονος σημασίας και αδιαφορούσαν να περικόψουν τα μικροπρονόμια της τάδε ή δείνα οικονομικής ομάδας αφού φαινόντουσαν πως λίγο επηρέαζαν την δική τους ζωή. Η εποχή του Δε Βαριέσαι έληξε όταν συνειδητοποιήσαμε πως όλα αυτά τα οποία δηκτικά σχολιάζαμε αλλά στην πράξη επιτρέπαμε έχουν συνέπειες οι οποίες τελικά μας αφορούν και τους ίδιους.

Η πτώση του βιοτικού επιπέδου δεν είναι αποτέλεσμα των Μνημονίων, αλλά της χρεωκοπίας του Δημοσίου, το οποίο δεν μπορούσε πλέον να δανείζεται και να μοιράζει λεφτά. Αντιθέτως, χάρη στα Μνημόνια, το Ελληνικό κράτος (το οποίο μόλις το 2014 κατόρθωσε να αποκτήσει ένα μικρό πρωτογενές πλεόνασμα) μπόρεσε να μαλακώσει την ανάγκη προσαρμογής: χωρίς τα προγράμματα, η εξίσωση πρωτογενών δαπανών-εξόδων θα έπρεπε να είχε γίνει κατευθείαν και απότομα από το 2010.

Την Κυριακή, λοιπόν, σκεφτόμαστε το συμφέρον μας και επιλέγουμε τον δύσκολο δρόμο των μεταρρυθμίσεων μέσα στην Ευρώπη και όχι τις ψευδαισθήσεις όσων νομίζουν πως υπάρχει εναλλακτική οδός. Τα αγαθά, άλλωστε, κόποις κτώνται.

June 24, 2015

Oase1 had a Neandertal ancestor no earlier than ~200 years before his time

Several important conclusions of the discovery that Oase1 had a Neandertal ancestor 4-6 generations before his time (37-42 thousand years ago):
  • This is a smoking gun that modern humans interbred with Neandertals, following up on the publication of the Ust'Ishim and Kostenki-14 genomes; these two had longer Neandertal chunks than modern humans, from which it was estimated that their Neandertal admixture happened more than 50,000 years ago, roughly what one gets when looking at Neandertal chunks in modern humans alone. The Oase1 has even longer Neandertal chunks, and Neandertal admixture happened in its very recent past. 
  • So, it seems that Neandertal admixture was not a one-off event but is bracketed at least by the period 50-40 thousand years ago and happened in at least two places: Europe and the Near East.
  • The fact that the earliest European sample (N=1) has a recent Neandertal ancestor indicates that Neandertal admixture in the earliest Europeans cannot have been extremely rare or non-existent; if it were, the chances of finding one with the first try would be extremely low.
  • It is unlikely that Neandertals were killed off by modern humans immediately after the arrival of the latter in Europe, as the Oase1 is dated well after the arrival of modern humans to Europe.
  • Modern Europeans don't seem to be particularly related to the population of Oase1. After one substracts contamination and Neandertal admixture, what is left over is actually closer to East Asians than modern Europeans. But, it's equally close to East Asians and European hunter-gatherers. This can be explained if modern Europeans have ancestry from the mysterious "Basal Eurasians" via the Neolithic farmers.
Why did the Neandertals (and the significantly-Neandertal admixed AMH like Oase1) disappear? My bet is on the Campanian Ignibrite eruption.

Nature (2015) doi:10.1038/nature14558

An early modern human from Romania with a recent Neanderthal ancestor

Qiaomei Fu, Mateja Hajdinjak, Oana Teodora Moldovan, Silviu Constantin, Swapan Mallick, Pontus Skoglund, Nick Patterson, Nadin Rohland, Iosif Lazaridis, Birgit Nickel, Bence Viola, Kay Prüfer, Matthias Meyer, Janet Kelso, David Reich & Svante Pääbo

Neanderthals are thought to have disappeared in Europe approximately 39,000–41,000 years ago but they have contributed 1–3% of the DNA of present-day people in Eurasia1. Here we analyse DNA from a 37,000–42,000-year-old2 modern human from Peştera cu Oase, Romania. Although the specimen contains small amounts of human DNA, we use an enrichment strategy to isolate sites that are informative about its relationship to Neanderthals and present-day humans. We find that on the order of 6–9% of the genome of the Oase individual is derived from Neanderthals, more than any other modern human sequenced to date. Three chromosomal segments of Neanderthal ancestry are over 50 centimorgans in size, indicating that this individual had a Neanderthal ancestor as recently as four to six generations back. However, the Oase individual does not share more alleles with later Europeans than with East Asians, suggesting that the Oase population did not contribute substantially to later humans in Europe.


June 20, 2015

DNA from hot climates technically feasible

From the paper:
Ten petrous bones were selected from archaeological specimens, representing a wide range of geographical locations and climatic contexts (Table 1, for repository information see S1 File). The specimens were selected from Central Europe, Central Asia, Southeast Asia, the Levant, Anatolia, and North Africa. The specimens are from Holocene archaeological contexts dated to between 10,000–1,800 calibrated years before present (cal. BP). The samples from Nubia, Jordan and Turkmenistan are from hot and arid regions. The sample from Turkey is from the Eastern Mediterranean (northwestern Turkey); the samples from Hungary and Serbia are from the Carpathian Basin/Southeast Europe, while the two samples from Cambodia and Vietnam are from tropical/subtropical Southeast Asia. We also included a metatarsal bone for one Neolithic individual from Hungary (Polgár Ferenci hát, PF280-443) as a control to confirm the differences between petrous and non-petrous reported in the previous study [8].
It has recently been demonstrated [8] that petrous bone samples yield exceptionally high percentages of endogenous ancient DNA. Here we have shown that both the total amount of endogenous DNA that can be recovered as well as the percentage of all reads that represents endogenous DNA vary substantially for different parts of the petrous bone. Our results have several implications for aDNA studies. The results support the hypothesis that dense bone parts are especially suitable for ancient DNA research, with the densest part of the petrous bone, that which composes the otic capsule, providing the best results. For our samples the yields obtained for this part (part C) exceed those obtained for part B (i.e. dense bone part of the petrous outside the otic capsule) by up to 65-fold and those from part A by up to 177-fold. It is therefore apparent that while high endogenous yields can be obtained from part B, and hence from any dense part in the petrous, optimal yields should be obtained from bone sample taken directly from the otic capsule.
Finally, our results show that endogenous yields from the five samples which originated from hot (either arid or humid) regions were always lower than 1% including extractions from part C of the petrous bone. However, deamination patterns suggest for two (Ain Ghazal and Vat Komnou) of the three samples for which we obtained sufficient numbers of reads that the obtained sequences are likely endogenous to the bones (S3 Fig). In contrast, the deamination pattern for the third sample, Man Bac, suggests that the human reads obtained are more likely to represent contamination than endogenous ancient DNA. These results suggest that it may be possible to obtain endogenous DNA from part C also for samples with relatively low amounts of endogenous DNA from hot environments, although extreme caution will be necessary in the interpretation of the results obtained from such samples.

PLoS ONE 10(6): e0129102. doi:10.1371/journal.pone.0129102

Optimal Ancient DNA Yields from the Inner Ear Part of the Human Petrous Bone

Ron Pinhasi et al.

The invention and development of next or second generation sequencing methods has resulted in a dramatic transformation of ancient DNA research and allowed shotgun sequencing of entire genomes from fossil specimens. However, although there are exceptions, most fossil specimens contain only low (~ 1% or less) percentages of endogenous DNA. The only skeletal element for which a systematically higher endogenous DNA content compared to other skeletal elements has been shown is the petrous part of the temporal bone. In this study we investigate whether (a) different parts of the petrous bone of archaeological human specimens give different percentages of endogenous DNA yields, (b) there are significant differences in average DNA read lengths, damage patterns and total DNA concentration, and (c) it is possible to obtain endogenous ancient DNA from petrous bones from hot environments. We carried out intra-petrous comparisons for ten petrous bones from specimens from Holocene archaeological contexts across Eurasia dated between 10,000-1,800 calibrated years before present (cal. BP). We obtained shotgun DNA sequences from three distinct areas within the petrous: a spongy part of trabecular bone (part A), the dense part of cortical bone encircling the osseous inner ear, or otic capsule (part B), and the dense part within the otic capsule (part C). Our results confirm that dense bone parts of the petrous bone can provide high endogenous aDNA yields and indicate that endogenous DNA fractions for part C can exceed those obtained for part B by up to 65-fold and those from part A by up to 177-fold, while total endogenous DNA concentrations are up to 126-fold and 109-fold higher for these comparisons. Our results also show that while endogenous yields from part C were lower than 1% for samples from hot (both arid and humid) parts, the DNA damage patterns indicate that at least some of the reads originate from ancient DNA molecules, potentially enabling ancient DNA analyses of samples from hot regions that are otherwise not amenable to ancient DNA analyses.


June 18, 2015

Kennewick Man was a Native American

Nature (2015) doi:10.1038/nature14625

The ancestry and affiliations of Kennewick Man

Morten Rasmussen, Martin Sikora, Anders Albrechtsen, Thorfinn Sand Korneliussen, J. Víctor Moreno-Mayar, G. David Poznik, Christoph P. E. Zollikofer, Marcia S. Ponce de León, Morten E. Allentoft, Ida Moltke, Hákon Jónsson, Cristina Valdiosera, Ripan S. Malhi, Ludovic Orlando, Carlos D. Bustamante, Thomas W. Stafford Jr, David J. Meltzer, Rasmus Nielsen & Eske Willerslev

Kennewick Man, referred to as the Ancient One by Native Americans, is a male human skeleton discovered in Washington state (USA) in 1996 and initially radiocarbon-dated to 8,340–9,200 calibrated years before present (BP)1. His population affinities have been the subject of scientific debate and legal controversy. Based on an initial study of cranial morphology it was asserted that Kennewick Man was neither Native American nor closely related to the claimant Plateau tribes of the Pacific Northwest, who claimed ancestral relationship and requested repatriation under the Native American Graves Protection and Repatriation Act (NAGPRA). The morphological analysis was important to judicial decisions that Kennewick Man was not Native American and that therefore NAGPRA did not apply. Instead of repatriation, additional studies of the remains were permitted2. Subsequent craniometric analysis affirmed Kennewick Man to be more closely related to circumpacific groups such as the Ainu and Polynesians than he is to modern Native Americans2. In order to resolve Kennewick Man’s ancestry and affiliations, we have sequenced his genome to ~1× coverage and compared it to worldwide genomic data including the Ainu and Polynesians. We find that Kennewick Man is closer to modern Native Americans than to any other population worldwide. Among the Native American groups for whom genome-wide data are available for comparison, several seem to be descended from a population closely related to that of Kennewick Man, including the Confederated Tribes of the Colville Reservation (Colville), one of the five tribes claiming Kennewick Man. We revisit the cranial analyses and find that, as opposed to genomic-wide comparisons, it is not possible on that basis to affiliate Kennewick Man to specific contemporary groups. We therefore conclude based on genetic comparisons that Kennewick Man shows continuity with Native North Americans over at least the last eight millennia.