February 02, 2005

Ancient Neanderthal mtDNA from Iberia

Molecular Biology and Evolution (published online)

Neandertal Evolutionary Genetics; Mitochondrial DNA Data from the Iberian Peninsula

Carles Lalueza-Fox et al.


Mitochondrial DNA (mtDNA) was retrieved for the first time from a Neandertal from the Iberian Peninsula, excavated from the El Sidrón Cave (Asturias, North of Spain), and dated to circa 43,000 YA. The sequence suggests that Iberian Neandertals were not genetically distinct from those of other regions. An estimate of effective population size indicates that the genetic history of the Neandertals was not shaped by an extreme population bottleneck associated with the glacial maximum of 130 KYA. A high level of polymorphism at sequence position 16,258 reflects deeply rooted mtDNA lineages, with the time to the most recent common ancestor (TMRCA) at ca. 250 KYA. This coincides with the full emergence of the "classical" Neandertal morphology and fits chronologically with a proposed speciation event of H. neanderthalensis.


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