Estimating the IQ of states of the USA

From the paper:




Intelligence (article in press)

Estimating state IQ: Measurement challenges and preliminary correlates

Michael A. McDaniel

Abstract

The purpose of this study is threefold. First, an estimate of state IQ is derived and its strengths and limitations are considered. To that end, an indicator of downward bias in estimating state IQ is provided. Two preliminary causal models are offered that predict state IQ. These models were found to be highly predictive of state IQ, yielding multiple R's of 0.83 and 0.89. Second, the extent to which state IQ predicts state outcome variables (e.g., gross state product, health, violent crime, and government effectiveness) is estimated. State IQ shows positive correlations with gross state product, health, and government effectiveness and negative correlations with violent crime. These results are consistent with the extent to which IQ predicts outcomes at the level of the individual. Third, a research agenda is provided for improving estimates of state IQ, identifying factors that cause differences in state IQ, and delineating the role of IQ in predicting important variables.

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Brain size is not a good indicator of the evolution of human intelligence

Intelligence (Article in Press)

The evolution of human intelligence and the coefficient of additive genetic variance in human brain size

Geoffrey F. Millera and Lars Penke

Abstract

Most theories of human mental evolution assume that selection favored higher intelligence and larger brains, which should have reduced genetic variance in both. However, adult human intelligence remains highly heritable, and is genetically correlated with brain size. This conflict might be resolved by estimating the coefficient of additive genetic variance (CVA) in human brain size, since CVAs are widely used in evolutionary genetics as indexes of recent selection. Here we calculate for the first time that this CVA is about 7.8, based on data from 19 recent MRI studies of adult human brain size in vivo: 11 studies on brain size means and standard deviations, and 8 studies on brain size heritabilities. This CVA appears lower than that for any other human organ volume or life-history trait, suggesting that the brain has been under strong stabilizing (average-is-better) selection. This result is hard to reconcile with most current theories of human mental evolution, which emphasize directional (more-is-better) selection for higher intelligence and larger brains. Either these theories are all wrong, or CVAs are not as evolutionarily informative as most evolutionary geneticists believe, or, as we suggest, brain size is not a very good index for understanding the evolutionary genetics of human intelligence.

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Rio de Janeiro Y chromosomes

See also Brazilian Y chromosomes.

Am J Hum Biol. 2006 Oct 12;18(6):829-837 [Epub ahead of print]

Y-chromosome genetic variation in Rio De Janeiro population.

Silva DA, Carvalho E, Costa G, Tavares L, Amorim A, Gusmao L.

The present-day Brazilian gene pool is known to be the outcome of an admixture process of populations from different origins, mainly Amerindians, Europeans, and Africans. It is also known that in Brazil, a wide variation in the admixture process occurred in different regions of the country or even in different subpopulations from the same region. In the present study, we aimed to characterize the male lineages present in the Rio de Janeiro population, the second most populated of the 26 Brazilian states. A random sample of 127 unrelated males from Rio de Janeiro was typed for 28 Y-chromosome-specific biallelic markers. In total, 17 different haplogroups were defined within our sample, most of them of European ancestry (88.1%). Those of sub-Saharan African origin (E3a) amounted to 7.9%, while only 2 males carried Amerindian lineages (characterized by the presence of an M3 mutation: haplogroup Q3). Using both Y-STR haplotype and Y-SNP haplogroup information, genetic distances were calculated between the subgroup of Rio de Janeiro males carrying European haplogroups and the Portuguese population. Low, nonsignificant, values were obtained. Thus, in contrast with what is observed in their female counterparts, the vast majority of the present Rio de Janeiro male gene pool is of European extraction, while the original Amerindian lineages are residual and much less frequent than the sub-Saharan component resulting from the slave trade. These observations can be interpreted as the signature of the strong gender asymmetry of the admixture processes in colonial systems.

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Discovering the ethnic roots of African Americans is difficult

It's great that scientists are beginning to critically examine the tall claims of many companies offering DNA tests for genealogy and ancestry. Over-interpretation of the results plagues the field, due both to individuals' confirmation bias or desire to get substantial information for the money spent, but also due to the willingness of companies to cater and re-inforce these desires.

Looking for roots in Africa? DNA search not easy

WASHINGTON (Reuters) - African-Americans hoping to use DNA to find their roots may have to look harder than previously thought, researchers said on Thursday in a study they said shows Africans are too genetically mixed to make tracing easy.

Several companies now offer to help Americans trace their African ancestry using mitochondrial DNA, which is passed from mother to daughter virtually unaltered.

"What's your tribe?" asks one. "Trace Your Roots Back in Time," offers another.

But biologist Bert Ely of the University of South Carolina and colleagues found that fewer than 10 percent of African-American mitochondrial DNA sequences that were analyzed can be matched to any single African ethnic group.

The news might disappoint people who cannot trace a long paper trail of ancestors. More than 11 million Africans were forcibly shipped to the Americas during the slave trade that peaked in the 17th and 18th centuries.

"The test that everybody does is the same test and it is all valid," Ely said in a telephone interview.

"It is just that some companies will over-interpret the data and give you the most likely result instead of all of the matches."

Working with colleagues at the University of Massachusetts and the University of Maryland, Ely looked at 3,700 mitochondrial DNA sequences from people in sub-Saharan Africa.

BMC Biology (open access)

African-American mitochondrial DNAs often match mtDNAs found in multiple African ethnic groups

Bert Ely et al.

Background

Mitochondrial DNA (mtDNA) haplotypes have become popular tools for tracing maternal ancestry, and several companies offer this service to the general public. Numerous studies have demonstrated that human mtDNA haplotypes can be used with confidence to identify the continent where the haplotype originated. Ideally, mtDNA haplotypes could also be used to identify a particular country or ethnic group from which the maternal ancestor emanated. However, the geographic distribution of mtDNA haplotypes is greatly influenced by the movement of both individuals and population groups. Consequently, common mtDNA haplotypes are shared among multiple ethnic groups. We have studied the distribution of mtDNA haplotypes among West African ethnic groups to determine how often mtDNA haplotypes can be used to reconnect Americans of African descent to a country or ethnic group of a maternal African ancestor. The nucleotide sequence of the mtDNA hypervariable segment I (HVS-I) usually provides sufficient information to assign a particular mtDNA to the proper haplogroup, and it contains most of the variation that is available to distinguish a particular mtDNA haplotype from closely related haplotypes. In this study, samples of general African-American and specific Gullah/Geechee HVS-I haplotypes were compared with two databases of HVS-I haplotypes from sub-Saharan Africa, and the incidence of perfect matches recorded for each sample.

Results

When two independent African-American samples were analyzed, more than half of the sampled HVS-I mtDNA haplotypes exactly matched common haplotypes that were shared among multiple African ethnic groups. Another 40% did not match any sequence in the database, and fewer than 10% were an exact match to a sequence from a single African ethnic group. Differences in the regional distribution of haplotypes were observed in the African database, and the African-American haplotypes were more likely to match haplotypes found in ethnic groups from West or West Central Africa than those found in eastern or southern Africa. Fewer than 14% of the African-American mtDNA sequences matched sequences from only West Africa or only West Central Africa.

Conclusions

Our database of sub-Saharan mtDNA sequences includes the most common haplotypes that are shared among ethnic groups from multiple regions of Africa. These common haplotypes have been found in half of all sub-Saharan Africans. More than 60% of the remaining haplotypes differ from the common haplotypes at a single nucleotide position in the HVS-I region, and they are likely to occur at varying frequencies within sub-Saharan Africa. However, the finding that 40% of the African-American mtDNAs analyzed had no match in the database indicates that only a small fraction of the total number of African haplotypes has been identified. In addition, the finding that fewer than 14% of African-American mtDNAs matched mtDNA sequences from a single African region suggests that few African Americans might be able to trace their mtDNA lineages to a particular region of Africa, and even fewer will be able to trace their mtDNA to a single ethnic group. However, no firm conclusions should be made until a much larger database is available. It is clear, however, that when identical mtDNA haplotypes are shared among many ethnic groups from different parts of Africa, it is impossible to determine which single ethnic group was the source of a particular maternal ancestor based on the mtDNA sequence.

Link

Neolithic goats

Goats Key to Spread of Farming, Gene Study Suggests

Goats accompanied the earliest farmers into Europe some 7,500 years ago, helping to revolutionize Stone Age society, a new study suggests.

The trailblazing farm animals were hardy and highly mobile traveling companions to ancient pioneers from the Middle East who introduced agriculture to Europe and elsewhere, researchers say.

The onset of farming ushered in the so-called Neolithic Revolution, when settled communities gradually replaced nomadic tribes and their hunter-gatherer lifestyles between 8000 and 6000 B.C.

A team of archaeologists and biologists has traced the origins of domesticated goats in Western Europe to the Middle East at the beginnings of the Neolithic period.

The study is based on DNA analysis of goat bones from a Stone Age cave in France and suggests the animals spread across Europe quickly after their introduction. (Get goat photos, facts, and more.)

Proc. Natl. Acad. Sci. USA, 10.1073/pnas.0602753103

Divergent mtDNA lineages of goats in an Early Neolithic site, far from the initial domestication areas

Helena Fernández et al.

Goats were among the first farm animals domesticated, 10,500 years ago, contributing to the rise of the "Neolithic revolution." Previous genetic studies have revealed that contemporary domestic goats (Capra hircus) show far weaker intercontinental population structuring than other livestock species, suggesting that goats have been transported more extensively. However, the timing of these extensive movements in goats remains unknown. To address this question, we analyzed mtDNA sequences from 19 ancient goat bones (7,300-6,900 years old) from one of the earliest Neolithic sites in southwestern Europe. Phylogenetic analysis revealed that two highly divergent goat lineages coexisted in each of the two Early Neolithic layers of this site. This finding indicates that high mtDNA diversity was already present >7,000 years ago in European goats, far from their areas of initial domestication in the Near East. These results argue for substantial gene flow among goat populations dating back to the early neolithisation of Europe and for a dual domestication scenario in the Near East, with two independent but essentially contemporary origins (of both A and C domestic lineages) and several more remote and/or later origins.

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Study paints bleak picture of ethnic diversity

By John Lloyd in London
Published: October 8 2006 22:08 | Last updated: October 8 2006 22:08

A bleak picture of the corrosive effects of ethnic diversity has been revealed in research by Harvard University’s Robert Putnam, one of the world’s most influential political scientists.

His research shows that the more diverse a community is, the less likely its inhabitants are to trust anyone – from their next-door neighbour to the mayor.

This is a contentious finding in the current climate of concern about the benefits of immigration. Professor Putnam told the Financial Times he had delayed publishing his research until he could develop proposals to compensate for the negative effects of diversity, saying it “would have been irresponsible to publish without that”.

The core message of the research was that, “in the presence of diversity, we hunker down”, he said. “We act like turtles. The effect of diversity is worse than had been imagined. And it’s not just that we don’t trust people who are not like us. In diverse communities, we don’t trust people who do look like us.”

Prof Putnam found trust was lowest in Los Angeles, “the most diverse human habitation in human history”, but his findings also held for rural South Dakota, where “diversity means inviting Swedes to a Norwegians’ picnic”.

When the data were adjusted for class, income and other factors, they showed that the more people of different races lived in the same community, the greater the loss of trust. “They don’t trust the local mayor, they don’t trust the local paper, they don’t trust other people and they don’t trust institutions,” said Prof Putnam. “The only thing there’s more of is protest marches and TV watching.”

British Home Office research has pointed in the same direction and Prof Putnam, now working with social scientists at Manchester University, said other European countries would be likely to have similar trends.

His 2000 book, Bowling Alone, on the increasing atomisation of contemporary society, made him an academic celebrity. Though some scholars questioned how well its findings applied outside the US, policymakers were impressed and he was invited to speak at Camp David, Downing Street and Buckingham Palace.

Prof Putnam stressed, however, that immigration materially benefited both the “importing” and “exporting” societies, and that trends “have been socially constructed, and can be socially reconstructed”.

In an oblique criticism of Jack Straw, leader of the House of Commons, who revealed last week he prefers Muslim women not to wear a full veil, Prof Putnam said: “What we shouldn’t do is to say that they [immigrants] should be more like us. We should construct a new us.”

From the Financial Times

New Anatomical Record on Flores hominid

On the heels of the recent paper on PNAS about the Flores hominid (aka "Hobbit"), a new paper in the Anatomical Record also questions the validity of Homo floresiensis. Here is the press release from the Field Museum:

CHICAGO -- What may well turn out to be the definitive work in a debate that has been raging in palaeoanthropology for two years will be published in the November 2006 issue of Anatomical Record.

The new research comprehensively and convincingly makes the case that the small skull discovered in Flores, Indonesia, in 2003 does not represent a new species of hominid, as was claimed in a study published in Nature in 2004. Instead, the skull is most likely that of a small-bodied modern human who suffered from a genetic condition known as microcephaly, which is characterized by a small head.

"It's no accident that this supposedly new species of hominid was dubbed the 'Hobbit;'" said Robert R. Martin, PhD, Curator of Biological Anthropology at the Field Museum and lead author of the paper. "It is simply fanciful to imagine that this fossil represents anything other than a modern human." The new study is the most wide-ranging, multidisciplinary assessment of the problems associated with the interpretation of the 18,000-year-old Flores hominid yet to be published. The authors include experts on:

* scaling effects of body size, notably with respect to the brain: Dr. Martin and Ann M. MacLarnon, PhD, School of Human & Life Sciences, Roehampton University in London;
* clinical and genetic aspects of human microcephaly: William B. Dobyns, PhD, Department of Human Genetics, University of Chicago; and
* stone tools: James Phillips, PhD, Departments of Anthropology at the University of Illinois at Chicago and the Field Museum.

This is just one of four separate research teams that have recently published evidence indicating concluding that the Flores hominid is far more likely to be a small-bodied modern human suffering from a microcephaly than a new species derived from Homo erectus, as was claimed in the original Nature paper.

Significantly, the second most recent publication to conclude that the "Hobbit" was microcephalic--another multidimensional study that was published in the September 5, 2006, issue of Proceedings of the National Academy of Sciences--includes a co-author who was also a co-author of the original publication in Nature. That scientist, R.P. Soejono of the National Archaeological Research Center in Jakarta, Indonesia, now writes that the Flores hominid was microcephalic rather than a new hominid species.

The Anatomical Record Part A Published Online: 9 Oct 2006

Flores hominid: New species or microcephalic dwarf?

Robert D. Martin et al.

Abstract

The proposed new hominid "Homo floresiensis" is based on specimens from cave deposits on the Indonesian island Flores. The primary evidence, dated at ~18,000 y, is a skull and partial skeleton of a very small but dentally adult individual (LB1). Incomplete specimens are attributed to eight additional individuals. Stone tools at the site are also attributed to H. floresiensis. The discoverers interpreted H. floresiensis as an insular dwarf derived from Homo erectus, but others see LB1 as a small-bodied microcephalic Homo sapiens. Study of virtual endocasts, including LB1 and a European microcephalic, purportedly excluded microcephaly, but reconsideration reveals several problems. The cranial capacity of LB1 ( ~400 cc) is smaller than in any other known hominid

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Jensen's default hypothesis rejected

A new article in Intelligence presents strong evidence against Jensen's default hypothesis that "group differences in IQ have the same genetic and environmental bases, in the same ratio, that underlie individual differences within a racial group." According to the authors, IQ scores are due both to intelligence, but also to the provisioning of information. Whites and Blacks do not differ in intelligence, but rather in the information that they have acquired. Whites and Blacks are able to answer questions correctness at the same rate when they both possess the same information: this indicates that their brains' processing efficiency is not worse than Whites'. It is in the test items for which Blacks do not possess the same information as Whites that they underperform. Moreover, Whites and Blacks both have the same ability to acquire new information, so it is rather a lack of stimulation rather than lack of any skill of acquiring new information that is the root of Black underperformance. From the paper:

In what ways are African-Americans deprived of access to information? Differences in exposure to information on the parts of African-Americans and Whites are an empirical fact. As noted by Fagan (2000), Hart and Risley (1995) conducted a longitudinal study on the frequency of verbal stimulation and the resulting language development of children from 1 to 3 years of age. They found that amount of exposure to language predicted the vocabulary development and the IQ scores of the children at three years. They also found that the children of professionals (typically, Whites) were exposed to five times the amount of words than were children of parents on welfare (typically, African-Americans). The Hart and Risley results tell us that the child's exposure to words in their homes during their first few years influences their later IQ. Whites and African-Americans differ in IQ by as early as 3 years (Montie and Fagan, 1988 and Peoples et al., 1995). Numerous studies (e.g. see reviews by Bjorklund, 2005 and Courage and Howe, 2002) have focused on the knowledge gained by infants through the infants' ability to process information and how that processing ability during the first year of life is predictive of later IQ (Fagan, 1992). All of these findings tell us that the search for racial differences in the kind of knowledge required to solve items on conventional IQ tests must begin in the first months and years of life.

Intelligence (online early)

Joseph F. Fagan, and Cynthia R. Holland

Abstract

African-Americans and Whites were asked to solve problems typical of those administered on standard tests of intelligence. Half of the problems were solvable on the basis of information generally available to either race and/or on the basis of information newly learned. Such knowledge did not vary with race. Other problems were only solvable on the basis of specific previous knowledge, knowledge such as that tested on conventional IQ tests. Such specific knowledge did vary with race and was shown to be subject to test bias. Differences in knowledge within a race and differences in knowledge between races were found to have different determinants. Race was unrelated to the g factor. Cultural differences in the provision of information account for racial differences in IQ.

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Head circumference and height in autism

According to this article, autistic individuals have a greater head circumference than normal people, but not greater than that of their parents. Their head circumference is also larger relative to their height.

I wish someone would give a standard battery of psychometric and anthropometric tests to a large sample of normal individuals. We so often get an impression of a person's character and competence from a quick glance, that I would be very surprised if there was no correlation between appearance and psychology that could be quantified.

Am J Med Genet A. 2006 Oct 4

Head circumference and height in autism: A study by the collaborative program of excellence in autism

Lainhart JE et al.

Data from 10 sites of the NICHD/NIDCD Collaborative Programs of Excellence in Autism were combined to study the distribution of head circumference and relationship to demographic and clinical variables. Three hundred thirty-eight probands with autism-spectrum disorder (ASD) including 208 probands with autism were studied along with 147 parents, 149 siblings, and typically developing controls. ASDs were diagnosed, and head circumference and clinical variables measured in a standardized manner across all sites. All subjects with autism met ADI-R, ADOS-G, DSM-IV, and ICD-10 criteria. The results show the distribution of standardized head circumference in autism is normal in shape, and the mean, variance, and rate of macrocephaly but not microcephaly are increased. Head circumference tends to be large relative to height in autism. No site, gender, age, SES, verbal, or non-verbal IQ effects were present in the autism sample. In addition to autism itself, standardized height and average parental head circumference were the most important factors predicting head circumference in individuals with autism. Mean standardized head circumference and rates of macrocephaly were similar in probands with autism and their parents. Increased head circumference was associated with a higher (more severe) ADI-R social algorithm score. Macrocephaly is associated with delayed onset of language. Although mean head circumference and rates of macrocephaly are increased in autism, a high degree of variability is present, underscoring the complex clinical heterogeneity of the disorder. The wide distribution of head circumference in autism has major implications for genetic, neuroimaging, and other neurobiological research.

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What makes us different

Time has a nice long article about what differentiates humans from other animals. An interesting tidbit:

And sometime in the next few weeks, a team led by molecular geneticist Svante Pääbo of the Max Planck Institute for Evolutionary Anthropology, in Leipzig, Germany, will announce an even more stunning achievement: the sequencing of a significant fraction of the genome of Neanderthals--the human-like species we picture when we hear the word caveman--who are far closer to us genetically than chimps are. And though Neanderthals became extinct tens of thousands of years ago, Pääbo is convinced he's on the way to reconstructing the entire genome of that long-lost relative, using DNA extracted, against all odds, from a 38,000-year-old bone.

Breast feeding doesn't make babies smarter

A new study in the British Medical Journal suggests that breast feeding does not have an effect on children's intelligence once you account for mother's IQ.

BMJ, doi:10.1136/bmj.38978.699583.55 (published 4 October 2006)

Effect of breast feeding on intelligence in children: prospective study, sibling pairs analysis, and meta-analysis

Geoff Der et al.

Objective To assess the importance of maternal intelligence, and the effect of controlling for it and other important confounders, in the link between breast feeding and children's intelligence.

Design Examination of the effect of breast feeding on cognitive ability and the impact of a range of potential confounders, in particular maternal IQ, within a national database. Additional analyses compared pairs of siblings from the sample who were and were not breast fed. The results are considered in the context of other studies that have also controlled for parental intelligence via meta-analysis.

Setting 1979 US national longitudinal survey of youth.

Subjects Data on 5475 children, the offspring of 3161 mothers in the longitudinal survey.

Main outcome measure IQ in children measured by Peabody individual achievement test.

Results The mother's IQ was more highly predictive of breastfeeding status than were her race, education, age, poverty status, smoking, the home environment, or the child's birth weight or birth order. One standard deviation advantage in maternal IQ more than doubled the odds of breast feeding. Before adjustment, breast feeding was associated with an increase of around 4 points in mental ability. Adjustment for maternal intelligence accounted for most of this effect. When fully adjusted for a range of relevant confounders, the effect was small (0.52) and non-significant (95% confidence interval -0.19 to 1.23). The results of the sibling comparisons and meta-analysis corroborated these findings.

Conclusions Breast feeding has little or no effect on intelligence in children. While breast feeding has many advantages for the child and mother, enhancement of the child's intelligence is unlikely to be among them.

Link

Height changes in Greece in the 20th century

Hormones (Athens). 2002 Oct-Dec;1(4):245-50.

Secular growth changes in the Hellenic population in the twentieth century.

Papadimitriou A, Chiotis D, Tsiftis G, Hatzisimeon M, Maniati M, Krikos X, Tzonou A, Dacou-Voutetakis C.

Statural growth is dependent on hereditary and environmental factors, i.e disease, nutrition. The improvement of socioeconomic conditions that took place during the 20th century resulted in a secular trend towards greater height and earlier sexual maturation. Greek society has changed dramatically from a mainly agricultural society at the beginning of the 20th century to a mainly urban one in the second half of the century, and during this period Greece became a developed country. The various studies examining the height of children living in Athens during this period show a gradual increase in the height of children, the difference of the mean height between 2001 and 1928 being 11.8 cm and 7.3 cm for 17 year old boys and girls, respectively. The difference in mean height was present at all ages. The difference in final height was mainly due to prepubertal growth. Girls at the age of 10 and boys at 11 years were about 8 cm taller in 2001 than in 1928. A growth study carried out on conscripts in 1990 found no significant difference in the height of males coming from urban or rural areas of the country, whereas such a difference was detected in 1968, rural men being significantly shorter than urban ones in 1968. There are only a few studies on the sexual maturation of Greek children. The available data suggest a secular trend towards earlier puberty in females; however, this can not be substantiated for males. Menarcheal age in Greek girls showed a positive secular change that is in agreement with the observed trend for earlier pubertal maturation in girls. In conclusion, Greek children in the 20th century experienced a positive secular trend in stature which also includes final height. A secular trend for earlier sexual maturation can be shown only for girls.

Link

Stability of personality from elementary school to midlife

J Pers Soc Psychol. 2006 Oct;91(4):763-79.

A first large cohort study of personality trait stability over the 40 years between elementary school and midlife.

Hampson SE, Goldberg LR.

This report provides some initial findings from an investigation of the relations between childhood Big Five personality traits assessed by elementary school teachers and similar traits assessed 40 years later by self-reports at midlife (N = 799). Short-term (1-3 years) test-retest reliabilities were lower (.22-.53) in childhood when personality was developing than they were in adulthood (.70-.79) when personality stability should be at its peak. Stability coefficients across the 40-year interval between the childhood assessment and the 2 measures of adulthood personality were higher for Extraversion (e.g., .29) and Conscientiousness (e.g., .25) than for Openness (e.g., .16), Agreeableness (e.g., .08), and Neuroticism (e.g., .00). Construct continuity between childhood and adulthood was evaluated by canonical analysis and by structural equation modeling and indicated continuity at both a broad, two-dimensional level and at the level of the Big Five. The findings are discussed in relation to A. Caspi, B. W. Roberts, and R. L. Shiner's (2005) principles of rank-order personality stability.

Link

Ancient Greco-Roman hair dyes used nanotechnology

Ancient hair dye used nanotechnology

A 2000-year-old recipe for hair dye shows Ancient Greeks and Romans used nanotechnology to permanently colour grey hair black, say experts.

Dr Philippe Walter of the French state museum agency's Centre for Research and Restoration and colleagues report their findings online in the journal Nano Letters.

The researchers made up a batch of dye according to a recipe used since Greco-Roman times, which includes a mixture of lead oxide and slaked lime.

They soaked 50 milligrams of blond human hair in the dye for three days, then studied the hair closely.

The hair turned progressively black and when the researchers took cross-sections of hair and studied it under the microscope they found nanocrystals of lead sulfide inside the hair shaft.

The lead in the lead oxide had reacted with sulfur from the amino acids found in hair keratins, the scientists say, giving the black colour.

They say the 5 nanometre lead sulfide crystals look very much like lead sulfide quantum dots that are made today by advanced materials science methods.

The researchers say their discovery might help develop new mineral-based nanomaterials.

Dr Ivan Kempson, a materials scientist and research fellow at the University of South Australia, is impressed with the research.

"It's the highest resolution and most detailed study of the incorporation of a metal like lead into hair," he says.

Kempson says the findings are interesting for his own work, which looks at how hair takes up metals from the environment.

But he says it is not yet clear how the sulfur in the keratin is made available to interact with the lead in the hair.

Kempson says the research is also of interest to the cosmetics industry in developing hair dyes.

"If you know how they penetrate the hair and how they react within the hair then you can develop better cosmetic products," he says.

The research team includes a member from L'Oréal cosmetics company.

Nano Lett., ASAP Article 10.1021/nl061493u S1530-6984(06)01493-7

Early Use of PbS Nanotechnology for an Ancient Hair Dyeing Formula

Philippe Walter et al.

Abstract:
Lead-based chemistry was initiated in ancient Egypt for cosmetic preparation more than 4000 years ago. Here, we study a hair-dyeing recipe using lead salts described in text since Greco-Roman times. We report direct evidence about the shape and distribution of PbS nanocrystals that form within the hair during blackening. It is remarkable that the composition and supramolecular organization of keratins can control PbS nanocrystal growth inside a hair.

Link

Adaptive evolution in Myostatin a muscle growth regulator

A pre-print in AJHG discusses Myostatin, a negative regulator of muscle growth. Loss of function mutations in Myostatin cause organisms to grow bigger muscles. According to this study, two variants of this gene have been under recent positive selection, reaching relatively high frequencies in sub-Saharan Africans but being rare elsewhere.

American Journal of Human Genetics (preprint)

Human adaptive evolution at Myostatin, a regulator of muscle growth

Matthew A. Saunders et al.

Myostatin (GDF8) is a negative regulator of muscle growth in mammals and loss of-function mutations are associated with increased skeletal muscle mass in mice, cattle and humans. Here we show that positive natural selection has acted on human nucleotide variation at GDF8 as the observed ratio of non-synonymous to synonymous changes among humans is significantly greater than expected under the neutral model and is strikingly different from patterns observed across mammalian orders. Furthermore, extended haplotypes around GDF8 suggest that two amino acid variants have been subject to recent positive selection. Both mutations are rare among non-Africans yet are at frequencies of up to 31% in sub-Saharan Africans. These signatures of selection at the molecular level suggest that human variation at GDF8 is associated with functional
differences.

Link (preprint pdf)

DNA to be extracted from Kent's cavern tooth

According to the Scotsman:

SCIENTISTS are attempting to extract DNA for the first time from the fossilised bones thought to be of a Neanderthal man who roamed Britain 35,000 years ago.

Experts plan to use a tooth from an upper jaw to establish whether the closest relative of modern humans lived on the British Isles later than it was once thought.

The fragment of an upper jaw, which was found in 1926 at Kent's Cavern in Devon, was originally thought to be human, but experts now think it could date back even further.

Chris Stringer, research leader in Human Origins at the Natural History Museum in London, said it was a critical test that could have historic results. The only late Neanderthal fossils on the British Isles were found on the Channel Islands around 1910.

However, Stringer said the teeth discovered at the site date back to a time when the island was joined to France around 50,000 years ago.

The director of the Ancient Human Occupation of Britain (AHOB) project said: "Neanderthal DNA is very distinct and would show up clearly in tests. It is a critical test as this could be the first late Neanderthal fossil on mainline Britain.

"But it is also historic if there is modern human DNA as this would prove they were here earlier than previously thought.

"Neanderthals are so close to us in time, living 30,000 to 40,000 years ago, and a closely related species. We have lots of Neanderthal tools but no fossils. The team is excited about the tests, but we need a bit of luck as the DNA may not have survived."

The roots, crown, size and shape of the tooth, which is thought to date back 35,000 years, would also be studied.

Torquay Museum in Devon, which looks after the piece of jaw bone, has agreed in principle to the DNA and carbon dating tests, Stringer said.

The group, which found evidence which dated the arrival of primitive ancestors in Britain to 700,000 years ago, 200,000 years earlier than previous findings, includes archaeologists, paleontologists and geologists from the Natural History Museum, the British Museum, Royal Holloway, University of London, and the University of Durham.

AHOB was set up in 2001 and funded for five years with £1.2m from the Leverhulme Trust which provides grants for education and research.

The second phase of research, which is called AHOB2 and runs until 2010, starts today after the Leverhulme Trust provided a £999,000 grant.

The next phase will include comparative studies in continental Europe.

The new project will also test the theory that there were no humans in Britain between 180,000 and 60,000 years ago due to the creation of the English Channel, making access to Britain more difficult.