mtDNA Variation Predicts Population Size in Humans and Reveals a Major Southern Asian Chapter in Human Prehistory
Quentin D. Atkinson et al.
The relative timing and size of regional human population growth following our expansion from Africa remains unknown. Human mitochondrial DNA (mtDNA) diversity carries a legacy of our population history. Given a set of sequences, we can use coalescent theory to estimate past population size through time and draw inferences about human population history. However, recent work has challenged the validity of using mtDNA diversity to infer species population sizes. Here we use Bayesian coalescent inference methods, together with a global dataset of 357 human mtDNA coding region sequences, to infer human population sizes through time across eight major geographic regions. Our estimates of relative population sizes show remarkable concordance with the contemporary regional distribution of humans across Africa, Eurasia and the Americas, indicating that mtDNA diversity is a good predictor of population size in humans. Plots of population size through time show slow growth in sub-Saharan Africa beginning 143-193kya, followed by a rapid expansion into Eurasia after the emergence of the first non-African mtDNA lineages 50-70kya. Outside Africa, the earliest and fastest growth is inferred in Southern Asia
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