tag:blogger.com,1999:blog-7785493.post3628879034789266870..comments2024-01-04T04:11:55.717+02:00Comments on Dienekes’ Anthropology Blog: Nuclear sequences of mitochondrial origin and gene flow in Pleistocene AfricaDienekeshttp://www.blogger.com/profile/02082684850093948970noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-7785493.post-71849426501528128242013-09-02T17:11:27.754+03:002013-09-02T17:11:27.754+03:00Please also read Genome Digging: Insight into the ...Please also read <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0014278" rel="nofollow">Genome Digging: Insight into the Mitochondrial Genome of Homo</a><br />by Ovchinnikov & Kholina, 2010.<br />No comparison with Denisova was yet available, though the scientific world "should" already have picked up the divergence of African mtDNA compared to especially the omnipresent mtAncestor-1 (numt-1) - even in relation with non-African mtDNA. Actually, it is hard NOT to see in table 1 some intermediate position of non-African mtDNA between Neanderthal and African mtDNA for the higher scores. Lower scores identify older inclusions, where differences with Neanderthal, non-African and African mtDNA are "naturally" levelled off. However, the highest scores together (resp. in numt-1, numt-4 and numt-6) apparently still indicate a closer relationship of Neanderthal mtDNA with ancestral mtDNA in the autosomes, and a more distant relationship with African mtDNA, but - strikingly - an <i>intermediate</i> relationship with non-African mtDNA. This should imply a fundamental confict with the current mtDNA phylogenitic tree, and actually should rather <i>reverse</i> the tree, with African diversity the result of more recent branching and the root closer to eg. mtDNA U, X and B.<br />At least numt-1 (mtAncestor-1) is omnipresent among modern humans, IMO poor evidence of hybridization. A different picture can be discerned for numt-5, the insert of chromosome 11, that is prevalent in non-African populations but not in African populations, and moreover has Neanderthal and modern humans as virtually equivalent outgroups, and is still vaguely reminiscent of Denisovan mtDNA. Now, <i>that</i> is a clear indication of hybridization events in the past! I remain unconvinced the same applies to mtAncestor-1.Rokushttps://www.blogger.com/profile/13883125231922541439noreply@blogger.comtag:blogger.com,1999:blog-7785493.post-11585143503646848572013-09-01T22:17:37.585+03:002013-09-01T22:17:37.585+03:00They choose it for a couple reasons, mostly bad. T...They choose it for a couple reasons, mostly bad. The biggest one is to silence critics. If they publish in a journal it has fixed reviewers and they all tend to be stacked towards a set of beliefs, so they can get review of obvious mistakes in methodology and data without getting challenged on the actual conclusions, which is usually what's questionable. The second is they often plan to write books and feel if they publish the results publicly they won't get a book deal.<br /><br />And if you don't publish a book you don't get tenure. But if everyone played by the same rules then you would not have to have it so everyone needed to publish a book. I mean, that is the problem, not the solution to anything. Doing science in such a way as it's going to sell the most books has led to a lot of the junk science we look at every day.<br /><br />Fiend of 9 worldshttps://www.blogger.com/profile/17712083368615685458noreply@blogger.comtag:blogger.com,1999:blog-7785493.post-80899129996520973632013-08-30T16:35:17.213+03:002013-08-30T16:35:17.213+03:00Someone wanted $50 for this rather questionable pa...Someone wanted $50 for this rather questionable paper for an educational institution access heavily invested in the top 1,000+ publications - for free, for members.<br /><br />Sorry, ain't going to happen.<br /><br />Next step is active outcasting of such looser for-profit group. <br /><br />No scientists should choose such media.eurologisthttps://www.blogger.com/profile/03440019181278830033noreply@blogger.comtag:blogger.com,1999:blog-7785493.post-24275761307182056332013-08-30T13:11:20.862+03:002013-08-30T13:11:20.862+03:00I found the same close relationship with Denisovan...I found the same close relationship with Denisovans like the mtAncestor-1 insert in chromosome 1 for the mtDNA insertion in chromosome 11. Actually, I wonder both inserts are indeed phylogenetically closer to Denisovan mtDNA, or rather indicative of ancestral mtDNA that was slightly different from the one commonly deduced using outgroups. Such mtDNA as a reference would naturally imply a much more complicated history of mutations and back mutations for modern mtDNA.Rokushttps://www.blogger.com/profile/13883125231922541439noreply@blogger.com