tag:blogger.com,1999:blog-7785493.post2398938688336357947..comments2024-01-04T04:11:55.717+02:00Comments on Dienekes’ Anthropology Blog: Y chromosome haplogroup I and disease-based selectionDienekeshttp://www.blogger.com/profile/02082684850093948970noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-7785493.post-9971312386273801562013-08-26T22:14:02.300+03:002013-08-26T22:14:02.300+03:00In 2012 the authors published more papers showing ...In 2012 the authors published more papers showing that the genes in the I ydna affected heart disease,<br />"Further analysis showed that men with haplogroup I showed downregulation of adaptive immunity as well as upregulation of inflammatory response pathways in their macrophages (immune system cells)"<br />http://dienekes.blogspot.com/2012/02/y-chromosomes-and-coronary-artery.htmlmatthttps://www.blogger.com/profile/14331613045178862418noreply@blogger.comtag:blogger.com,1999:blog-7785493.post-18966063545965164802012-05-24T07:52:03.473+03:002012-05-24T07:52:03.473+03:00Or how about the idea that 'the mechanism of a...Or how about the idea that 'the mechanism of action' of all diseases of 'crowding' such as the plague, tb, aids etc is similar and therefore those tribes with earlier experience of crowding (Farmers/pastoralists) would fare better against them than the hunter gatherers.Amir Timurhttps://www.blogger.com/profile/12212341982542201335noreply@blogger.comtag:blogger.com,1999:blog-7785493.post-72252482931316527202010-06-28T19:21:38.542+03:002010-06-28T19:21:38.542+03:00"I don't understand why one's haplogr..."I don't understand why one's haplogroup should be of any import to HIV/Aids progression."<br /><br />And yet the correlation is there and presumably has some cause. <br /><br />If there is indeed a genetic cause, one can imagine that some disease that shared some mechanism with HIV/AIDS killed large numbers of people in one haplogroup but not the other, leaving the survivors of the affected haplogroup population with better biochemical defenses than the unaffected group. This would have had to have happened sometime after an IJ split, so probably sometime in the Holocene.Andrew Oh-Willekehttps://www.blogger.com/profile/02537151821869153861noreply@blogger.comtag:blogger.com,1999:blog-7785493.post-74976798701249755392010-06-26T09:06:11.411+03:002010-06-26T09:06:11.411+03:00An odd study. I don't understand why one's...An odd study. I don't understand why one's haplogroup should be of any import to HIV/Aids progression.<br /><br />Without sounding bigoted haplogroup I is mainly European with minor frequencies in Anatolia, Levantine and North Africa. HIV/Aids is principally a problem of Western societies and in Africa, some parts of the underdeveloped world like Thailand. It just follows the there are more Europeans, and Americans of European origins who happen to be haplogroup I than haplogroup J, so there will be more reporting with that illness who belong to haplogroup I. Haplogroup J is mainly Middle Eastern, and a minority one in Europe in in the Mediterranean zone of Europe.<br /><br />Anyway, I hope the study is of some use to someone.Anonymousnoreply@blogger.com