tag:blogger.com,1999:blog-7785493.post4011408650822049493..comments2024-01-04T04:11:55.717+02:00Comments on Dienekes’ Anthropology Blog: Putting it all together: DRACOS for fine-scale admixture estimationDienekeshttp://www.blogger.com/profile/02082684850093948970noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-7785493.post-22117727853768768182011-10-20T21:35:26.187+03:002011-10-20T21:35:26.187+03:00Great work D, you're a machine! (in a good way...Great work D, you're a machine! (in a good way :)Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-7785493.post-27681546650849194752011-10-20T21:15:14.380+03:002011-10-20T21:15:14.380+03:00Have you done any proof of concept runs of DRACOS?...<i>Have you done any proof of concept runs of DRACOS?</i><br /><br />Of course<br /><br /><i>How did they differ (or resemble) other approaches?</i><br /><br />DRACOS allows for fine-scale admixture estimation. The quadratic cost of ADMIXTURE and its idiosyncracies (e.g., getting lost in likelihood space and finding local minima) prohibits it from inferring fine-scale components on both performance and theoretical grounds.<br /><br />DRACOS can convert any Clusters Galore or MCLUST run into synthetic individuals that can be used in ADMIXTURE. You can think of it as turboboosting ADMIXTURE by doing the cluster inference for it, and ADMIXTURE is then used to do what it knows how, i.e., admixture proportions estimation.<br /><br />DRACOS-based results for long-range clines (e.g., Sub-Saharans vs. East Asians) are virtually identical to those produced by simple ADMIXTURE. For short-range ones, all the usual caveats enumerated in my recent post apply.<br /><br />http://dienekes.blogspot.com/2011/10/further-caution-on-admixture-estimates.htmlDienekeshttps://www.blogger.com/profile/02082684850093948970noreply@blogger.comtag:blogger.com,1999:blog-7785493.post-44628480239445727892011-10-20T20:51:13.879+03:002011-10-20T20:51:13.879+03:00Can't wait to see this - keep up the good work...Can't wait to see this - keep up the good work!pconroyhttps://www.blogger.com/profile/10312469574812832771noreply@blogger.comtag:blogger.com,1999:blog-7785493.post-25925420071144013882011-10-20T20:46:14.037+03:002011-10-20T20:46:14.037+03:00Have you done any proof of concept runs of DRACOS?...Have you done any proof of concept runs of DRACOS? How did they differ (or resemble) other approaches?Andrew Oh-Willekehttps://www.blogger.com/profile/02537151821869153861noreply@blogger.com